7th ISF

CHEM034 - Prohibiting Amyloid Beta Plaques in Alzheimer’s Patient by Using Phenolic Extracted From Vigna angularis (L.) Seed and Sprout


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Alzheimer's disease is one of the dementia conditions caused by degeneration of the function or structure of brain tissues, which is often found in the elderly. Alzheimer's is not a natural degeneration, but a degeneration caused by beta amyloid proteins that binds to brain cells, which reduces brain performance. This experiment had been conducted to study the ability to inhibit beta amyloid with phenolic substances extracted from Vigna angularis (L.) or Azuki red bean seed. Firstly, extracted phenolic from red bean seeds then measured the amount of phenolic and antioxidants to compare with the standard graph. After that, tested the phenolic with beta amyloid fibril gained from incubating lysozyme extracted from albumen with phosphate buffer and urea with the ratio of 10:1:1. Next 1, 2, and 3 proportions of phenolic was added to each experimental set respectively and then incubated these for 48 hours for measuring the weight of residue. It was found that the experimental set added with lysozyme, phosphate buffer, and urea using a ratio of 10:1:1:3, had the least amount of residue weight. When examined the residue with the microscope, it was noticed that its characteristic was thin and there was some smaller amount of beta amyloid fibril compared to the other controlled sets of which its lines characteristics were thicker. In the future, there might be some development of processing phenolic into food products and further studies of other antibiotics for curing Alzheimer's disease.

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Name :  

Thanakorn Chuanjaroenthanakul, Sirapob Musikawat

Email :  

64thanakorn.chu@pccphet.ac.th

Advisor :  

Suchaya Sriudom

School :  

Princess Chulabhorn Science High School Phetchaburi


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